The Effect of Intake of GliSODin on Minimal Erythema Dose (MED), a Randomised, Double-blind, Placebo-controlled, Parallel-group Study of Healthy Japanese

Abstract

Gliadin-combined superoxide dismutase (SOD)-rich Melon Extract (GME, trade name: GliSODin, ISOCELL Nutra S.A.S, France) has already demonstrated activation properties on the principal internal antioxidant enzymes, particularly SOD, Catalase and Glutathione Peroxidase. The purpose of this study was to assess the efficacy of GME in helping increase the Minimal Erythema Dose (MED) which plays a role in preventing sunburn.Forty-one healthy Japanese male subjects of skin phototypes II and III took either 250 mg / day of GME capsules or placebo capsules for eight weeks. The intake of GME induced a significant increase in the MED (5.1% versus -5.0% for the placebo group). This improvement in sun protection might be attributable to the increased antioxidative capacity induced by the intake of GME